Current Issue : January-March Volume : 2010 Issue Number : 1 Articles : 2 Articles
The study was to analyze the dynamic characteristics of ossicular chain under the stimulus frequencies, 125 Hz, 250 Hz, 500 Hz, 750 Hz, 1 kHz, 2 kHz, 3 kHz, 4 kHz, 5 kHz, 6 kHz, 7 kHz and 8 kHz, by finite element method. The finite element model of the ossicular chain of patients could be built by 3D image model of the ossicular chain based on the high resolution computed tomography. The displacement at the footplate would hardly occur when the ossicles was excited by the sound stimuli at frequency above 2 kHz. The presented result shows that the ossicular chain only could transmit the stimuli under 2000 Hz by the vibration of ossicles....
Diseases such as degenerative or rheumatoid arthritis are accompanied by joint destruction. Clinically applied tissue engineering technologies like autologous chondrocyte implantation, matrix assisted chondrocyte implantation, or in situ recruitment of bone marrow mesenchymal stem cells targets the treatment of traumatic defects or of early osteoarthritis. Inflammatory conditions in the joint hamper the application of tissue engineering during chronic joint diseases. Here, most likely, cartilage formation is impaired and engineered neocartilage will be degraded. These developments were underpinned by an earlier revolution in molecular biology and protein engineering as well as key advances in our understanding of rheumatoid arthritis pathogenesis. This review will focus on antibody engineering as the key driver behind our current and developing range of antirheumatic treatments....
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